Recent Publications

2005 - Present

Barton L.J., Roa-DeLaCruz L., Lehmann R., Lin B. The journey of a generation: advances and promises in the study of primordial germ cell migration. Dev. 2024. [Abstract]

Barton L.J., Sanny J. Dawon E.P., Nouzova M., Noriega F.G., Stadtfeld M., Lehmann R. Juvenile hormones direct primordial germ cell migration to the embryonic gonad. Curr Biol. 2023. [Abstract]

Grill S., Riley A., Selvaraj M., Lehmann R. HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare. PNAS. 2023. Abstract.

Lin B., Luo J., Lehmann R. An AMPK phosphoregulated RhoGEF feedback loop tunes cortical flow–driven amoeboid migration in vivo. Sci Adv. 2022. Abstract.

Slaidina M., Gupta S., Banisch T.U., Lehmann R. A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries. Genome Res. 2021. Abstract.

Banisch T.U., Slaidina M., Gupta S., Ho M., Gilboa L., Lehmann R. A transitory signaling center controls timing of primordial germ cell differentiation. Dev Cell. 2021. Abstract.

Lin B., Luo J., Lehmann R. Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo. Nat Comm. 2020. Abstract.

Trcek T, Douglas T.E., Grosch M, Shroff H, Rothenberg E, Lehmann R. Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters. Mol Cell. 2020. Abstract.

Slaidina M., Banisch T.U., Gupta S., and Lehmann, R. A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. Genes Dev. 2020. Abstract.

Lieber T, Jeedigunta SP, Palozzi JM, Lehmann R, Hurd TR. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Nature. 2019. Abstract

Grobler Y, Yun CY, Kahler DJ, Bergman CM, Lee H, Oliver B, Lehmann R. Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. PLoS Pathog. 2018 Nov 13;14(11):e1007445. Abstract

Kistler KE, Trcek T, Hurd TR, Chen R, Liang FX, Sall J, Kato M, Lehmann R. Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells. Elife. 2018 Sep 27;7. pii: e37949. Abstract

Abrams JM, Arkhipova IR, Belfort M, Boeke JD, Joan Curcio M, Faulkner GJ, Goodier JL, Lehmann R, Levin HL. Meeting report: mobile genetic elements and genome plasticity 2018. Mob DNA. 2018 Jun 22;9:21. Link

Lehmann, R. Matchmaking molecule for egg and sperm. Science. 2018. Sept 7. Vol. 361, Issue 6406, pp.974-975. Full Text

Teixeira FK and Lehmann R. Translational Control during Developmental Transitions. Cold Spring Harbor perspectives in biology. 2018. Aug 6. pii: a032987. Abstract

Coux RX, Teixeira FK, Lehmann R. L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary. Development. 2018 Apr 4;145(7). pii: dev160721. Abstract

Teixeira FK, Okuniewska M, Malone CD, Coux RX, Rio DC, Lehmann R. piRNA-mediated regulation of transposon alternative splicing in the soma and germ line. Nature. 2017 Dec 14;552(7684):268-272. Abstract

Pae J, Cinalli RM, Marzio A, Pagano M, Lehmann R. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. Dev Cell. 2017 Jul 24;42(2):130-142.e7. Abstract

LeBlanc M, Lehmann R. Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR. J Cell Biol.2017:216(9):2945-2958. Abstract

Trcek T, Lionnet T, Shroff, H, Lehmann R. mRNA quantification using single-molecule FISH in Drosophila embryos. Nat Protoc. 2017. 12(7):1326-1348. Abstract

Trcek T, Lehmann R. All about the RNA after all. Elife. 2017 Jan 24;6. pii: e24106. Abstract

Slaidina M, Lehmann R. Quantitative Differences in a Single Maternal Factor Determine Survival Probabilities among Drosophila Germ Cells. Curr Biol. 2017 Jan 23;27(2):291-297. Abstract

Hurd TR, Herrmann B, Sauerwald J, Sanny J, Grosch M, Lehmann R. Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster. Dev Cell. 2016 Dec 5;39(5):560-571. Abstract

Barton LJ, LeBlanc MG, Lehmann R. Finding their way: themes in germ cell migration. Curr Opin Cell Biol. 2016 Oct;42:128-137. Abstract

Lehmann R. Germ Plasm Biogenesis--An Oskar-Centric Perspective. Curr Top Dev Biol. 2016;116:679-707. doi: 10.1016/bs.ctdb.2015.11.024. Review. Abstract

Sanchez CG, Teixeira FK, Czech B, Preall JB, Zamparini AL, Seifert JR, Malone CD, Hannon GJ, Lehmann R. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell. 2016 Feb 4;18(2):276-90.Abstract

Hurd TR, Liang FX and Lehmann R Curly Encodes Dual Oxidase, Which Acts with Heme Peroxidase Curly Su to Shape the Adult Drosophila Wing. PLoS genetics. 2015:11(11). Abstract

Malone CD, Lehmann R and Teixeira FK The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila. Curr Opin Genet Dev (Oct 2015) 34:88-94. Abstract

Hurd TR, Sanchez CG, Teixeira FK, Petzold C, Dancel-Manning K, Wang JY, Lehmann R, Liang FX.(2015) Ultrastructural Analysis of Drosophila Ovaries by Electron Microscopy. Methods Mol Biol. 2015;1328:151-62. doi: 10.1007/978-1-4939-2851-4_11. Abstract

Teixeira FK, Sanchez CG, Hurd TR, Seifert JRK, Czech B, Preall JB, Hannon GJ, and Lehmann R, ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation Nature Cell Biology (May 2015) 7:689-96 Abstract

Yang N, Yu Z, Hu M, Wang M, Lehmann R, Xu RM, Structure of Drosophila Oskar reveals a novel RNA binding protein PNAS (Aug 2015) 201515568:1-8 Abstract

Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Xia W, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, and Perrimon N , The Transgenic RNAi Project at Harvard Medical School: Resources and Validation Genetics genetics Genetics (Aug 2015) 115:1-31 Abstract

Sanchez CG, Teixeira FK, Czech B, Preall JB, Zamparini AL, Seifert JR, Malone CD, Hannon GJ, Lehmann R. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell. 2015 Dec 6. pii: S1934-5909(15)00502-0. doi: 10.1016/j.stem.2015.11.004. Abstract

Trcek T, Grosch M, York A, Shroff H, Lionnet T, and Lehmann R, Drosophila germ granules are structured and contain homotypic mRNA clusters Nature Communications (Aug 2015) 6:1-12 Abstract

Slaidina M and Lehmann R, Translational control in germline stem cell development J Cell Biology (Oct 2014) 207:13-21 Abstract

Ren R, Liu H, Wang W, Wang M, Yang N, Dong YH, Gong W, Lehmann R, Xu RM , Structure and domain organization of Drosophila Tudor. Cell Research (May 2014) 10:1-4 Abstract

Cinalli RM and Lehmann R , A spindle-independent cleavage pathway controls germ cell formation in Drosophila Nature Cell Biology (Jul 2013) 15:839-45 Abstract

Seifert JRK, Lehmann R. Drosophila Primordial Germ Cell Migration Requires Epithelial Remodeling of the Endoderm. Dev. (Jun 2012). 139: 2101-2106. Abstract.

Lehmann R, Germline stem cells: origin and destiny. Cell Stem Cell (Jun 2012) 10:729-739 Abstract

Hurd TR, DeGennaro M and Lehmann R, Redox regulation of cell migration and adhesion. Trends in Cell Biology (Feb 2012) 22:107-15 Abstract

Rangan P, Malone CD, Navarro C, Newbold SP, Hayes PS, Sachidanandam R, Hannon GJ, Lehmann R, piRNA Production Requires Heterochromatin Formation in Drosophila. Curr Biol (Aug 2011) 21:1373-9 Abstract

DeGennaro M, Hurd TR, Siekhaus DE, Biteau B, Jasper H, Lehmann R, Peroxiredoxin stabilization of DE-Cadherin promotes primordial germ cell adhesion Developmental Cell (Feb 2011) 20:233-43 Abstract

Zamparini AL, Davis MY, Malone CD, Vieira E, Zavadil J, Sachidanandam R, Hannon GJ, Lehmann R., Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.Development (Aug 2011) 138:4039-50 Abstract

Lehmann R, Ruth Lehmann: germ cells do things differently. Interview by Caitlin Sedwick. Journal of Cell Biology (Sep 2011) 194:660-1 Abstract

Richardson BE and Lehmann R, Mechanisms guiding primordial germ cell migration: strategies from different organisms Nature Reviews Molecular Cell Biology (Jan 2010) 11:37-49 Abstract

Renault AD, Kunwar PS, Lehmann R., Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. Development (Jun 2010) 137:1815-23 Abstract

Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R., RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila.Nature Cell Biology (Jun 2010) 12:605-10 Abstract

Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM., Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.Genes and Development (Sep 2010) 24:1876-81 Abstract

Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H., Lifespan extension by preserving proliferative homeostasis in Drosophila.PLoS Genetics (Oct 2010) 14:xx Abstract

Rangan P, DeGennaro M, Jaime-Bustamante K, Coux RX, Martinho RG, Lehmann R, Temporal and spatial control of germ-plasm RNAs Current Biology (Jan 2009) 19:72-77 Abstract

Ricardo S, Lehmann R., An ABC transporter controls export of a Drosophila germ cell attractant Science (Feb 2009) 323:943-6 Abstract

de Las Heras JM, Martinho RG, Lehmann R and Casanova J, A functional antagonism between the pgc germline repressor and torso in the development of somatic cells EMBO Reports (Sep 2009) 10:1059-65Abstract

Navarro C, Bullock S and Lehmann R, Altered dynein-dependent transport in piRNA pathway mutants PNAS (Jun 2009) 106:9691-6 Abstract

Renault AD, Ricardo S, Kunwar PS, Santos A, Starz-Gaiano M, Stein JA and Lehmann R, Hedgehog does not guide migrating Drosophila germ cellsDevelopmental Biology (Apr 2009) 328:355-62 Abstract

Cinalli RM, Rangan P, Lehmann R., Germ cells are forever Cell (Feb 2008) 132:559-62 Abstract

Flatt T, Min KJ, D'Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M, Drosophila germ-line modulation of insulin signaling and lifespan PNAS (Apr 2008) 105:6368-73 Abstract

Thomson T, Liu N, Arkov A, Lehmann R, Lasko P, Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins Mechanisms of Development (Jun 2008) 125:865-873Abstract

Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG, Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Developmental Biology (Nov 2008) 323:197-206Abstract

Kunwar PS, Sano H, Renault AD, Barbosa V, Fuse N, Lehmann R., Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin. Journal of Cell Biology (Sep 2008) 183:157-168 Abstract

Rangan P, DeGennaro M and Lehmann R, Regulating gene expression in the Drosophila germ line Cold Spring Harbor Symposia on Quantitative Biology (2008) 73:1-8 Abstract

Sano H, Ricardo S, Lehmann R, Tumbling, an interactive way to move forward Sci. STKE (Nov 2007) 2007:63 Abstract

Gilboa L, Lehmann R., Changing places: a novel type of niche and stem cell coordination in the Drosophila ovary Cell Stem Cell (Sep 2007) 1:239-40Abstract

Barbosa V, Kimm N, Lehmann R, A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progressionGenetics (Aug 2007) 176:1967-77 Abstract

Strome S, Lehmann R, Germ versus soma decisions: lessons from flies and worms. Science (Apr 2007) 20:392-3 Abstract

Kunwar PS, Siekhaus DE and Lehmann R, In Vivo Migration: A Germ Cell Perspective Annual Reviews of Cell and Developmental Biology(Jun 2006) 0:0 Abstract

Gilboa L and Lehmann R, Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad Nature (Sep 2006) 443:97-100 Abstract

Arkov AL, Wang S, Ramos A and Lehmann R, The role of Tudor domains in germline development and polar granule architecture. Development (Oct 2006) 133:4053-62 Abstract

Renault AD, Lehmann R, Follow the fatty brick road: lipid signaling in cell migration Current Opinion in Genetics & Development (Aug 2006) 16:348-54 Abstract

Morris JZ, Hong A, Lilly MA and Lehmann R, twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesisDevelopment (Mar 2005) 132(6): 1165-74 Abstract

Sano H, Renault AD, Lehmann R, Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phophate phosphatases Wunen and Wunen2 Journal of Cell Biology (Nov 2005) 171:675-83 Abstract